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Small Scale
Peptide Synthesis > Modified
Peptides
Synthesis of Peptides Containing Modified Amino Acids
A wide range of modified amino acids may be incorporated into small scale synthetic
peptides with the primary limitation being the commercial availability of the required
Fmoc derivative. Because of the added expense of these specialized derivatives, many will
incur additional charges as indicated below. Since incorporation of modified amino acids
often will increase the difficulty of peptide synthesis, this may lead to lower yields of
less pure intended product. In some instances the complications of incorporating the
unusual amino acid can be minimized by its position in the peptide (e.g., we
recommend that P-Thr or P-Ser be kept within 15 residues of the N-terminus of the
peptide).
Derivative |
Surcharge/Residue
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25/50 µmol scale
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100 µmol scale
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Acetylated N-Terminus
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No additional charge
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No additional charge
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Amidated C-Terminus
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No additional charge
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No additional charge
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P-Thr or P-Ser |
$100 |
$200 |
P-Tyr |
$50 |
$100 |
Biotin |
$25 |
$50 |
Lys-Bio Amino Acid |
$100 / Amino Acid |
$200 / AA |
Wang Resin for Lys-Bio |
$25 |
$50 |
Fluoroscein |
$50 |
$100 |
Rhodamine |
$125 |
$250 |
| (Assymmetric) Dimethyl-Arg |
$60 |
$120 |
| Non-Radioactive Isotopes |
Actual cost of the non-radioactive, Fmoc derivative
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